Influenza Virus Specific CD8+ T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice
Identifieur interne : 000873 ( Main/Exploration ); précédent : 000872; suivant : 000874Influenza Virus Specific CD8+ T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice
Auteurs : E. M. Parzych [États-Unis] ; L. J. Dimenna [États-Unis] ; B. P. Latimer [États-Unis] ; J. C. Small [États-Unis] ; S. Kannan [États-Unis] ; B. Manson [États-Unis] ; M. O. Lasaro [États-Unis] ; E. J. Wherry [États-Unis] ; H. C. Ertl [États-Unis]Source :
- BioMed Research International [ 2314-6133 ] ; 2013.
Abstract
Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afforded by licensed vaccines through subtype-specific neutralizing antibodies is incomplete, especially when the vaccine antigens fail to closely match those of the circulating viral strains. Efforts are underway to generate a so-called universal influenza vaccine expressing conserved viral sequences that induce broad protection to multiple strains of influenza virus through the induction of CD8+ T cells. Here we assess the effect of a potent antiviral CD8+ T cell response on influenza virus infection of young and aged mice. Our results show that CD8+ T cell-inducing vaccines can provide some protection to young mice, but they exacerbate influenza virus-associated disease in aged mice, causing extensive lung pathology and death.
Url:
DOI: 10.1155/2013/876314
PubMed: 24187666
PubMed Central: 3800650
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000922
- to stream Pmc, to step Curation: 000922
- to stream Pmc, to step Checkpoint: 000607
- to stream Ncbi, to step Merge: 000978
- to stream Ncbi, to step Curation: 000978
- to stream Ncbi, to step Checkpoint: 000978
- to stream Main, to step Merge: 000874
- to stream Main, to step Curation: 000873
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza Virus Specific CD8<sup>+</sup> T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice</title><author><name sortKey="Parzych, E M" sort="Parzych, E M" uniqKey="Parzych E" first="E. M." last="Parzych">E. M. Parzych</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Drexel University, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drexel University, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dimenna, L J" sort="Dimenna, L J" uniqKey="Dimenna L" first="L. J." last="Dimenna">L. J. Dimenna</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I3">Columbia University, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Columbia University, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Latimer, B P" sort="Latimer, B P" uniqKey="Latimer B" first="B. P." last="Latimer">B. P. Latimer</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Drexel University, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drexel University, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Small, J C" sort="Small, J C" uniqKey="Small J" first="J. C." last="Small">J. C. Small</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I4">Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kannan, S" sort="Kannan, S" uniqKey="Kannan S" first="S." last="Kannan">S. Kannan</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I4">Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Manson, B" sort="Manson, B" uniqKey="Manson B" first="B." last="Manson">B. Manson</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I5">Cheyney University, Thornbury Township, PA 19139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cheyney University, Thornbury Township, PA 19139</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lasaro, M O" sort="Lasaro, M O" uniqKey="Lasaro M" first="M. O." last="Lasaro">M. O. Lasaro</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I6">Boehringer Ingelheim GMBH, Ridgefield, CT D6877, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boehringer Ingelheim GMBH, Ridgefield, CT D6877</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Wherry, E J" sort="Wherry, E J" uniqKey="Wherry E" first="E. J." last="Wherry">E. J. Wherry</name><affiliation wicri:level="2"><nlm:aff id="I7">Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ertl, H C" sort="Ertl, H C" uniqKey="Ertl H" first="H. C." last="Ertl">H. C. Ertl</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I7">Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24187666</idno><idno type="pmc">3800650</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800650</idno><idno type="RBID">PMC:3800650</idno><idno type="doi">10.1155/2013/876314</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000922</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000922</idno><idno type="wicri:Area/Pmc/Curation">000922</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000922</idno><idno type="wicri:Area/Pmc/Checkpoint">000607</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000607</idno><idno type="wicri:Area/Ncbi/Merge">000978</idno><idno type="wicri:Area/Ncbi/Curation">000978</idno><idno type="wicri:Area/Ncbi/Checkpoint">000978</idno><idno type="wicri:doubleKey">2314-6133:2013:Parzych E:influenza:virus:specific</idno><idno type="wicri:Area/Main/Merge">000874</idno><idno type="wicri:Area/Main/Curation">000873</idno><idno type="wicri:Area/Main/Exploration">000873</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Influenza Virus Specific CD8<sup>+</sup> T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice</title><author><name sortKey="Parzych, E M" sort="Parzych, E M" uniqKey="Parzych E" first="E. M." last="Parzych">E. M. Parzych</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Drexel University, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drexel University, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dimenna, L J" sort="Dimenna, L J" uniqKey="Dimenna L" first="L. J." last="Dimenna">L. J. Dimenna</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I3">Columbia University, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Columbia University, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Latimer, B P" sort="Latimer, B P" uniqKey="Latimer B" first="B. P." last="Latimer">B. P. Latimer</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Drexel University, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drexel University, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Small, J C" sort="Small, J C" uniqKey="Small J" first="J. C." last="Small">J. C. Small</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I4">Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kannan, S" sort="Kannan, S" uniqKey="Kannan S" first="S." last="Kannan">S. Kannan</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I4">Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Manson, B" sort="Manson, B" uniqKey="Manson B" first="B." last="Manson">B. Manson</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I5">Cheyney University, Thornbury Township, PA 19139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cheyney University, Thornbury Township, PA 19139</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lasaro, M O" sort="Lasaro, M O" uniqKey="Lasaro M" first="M. O." last="Lasaro">M. O. Lasaro</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I6">Boehringer Ingelheim GMBH, Ridgefield, CT D6877, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boehringer Ingelheim GMBH, Ridgefield, CT D6877</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Wherry, E J" sort="Wherry, E J" uniqKey="Wherry E" first="E. J." last="Wherry">E. J. Wherry</name><affiliation wicri:level="2"><nlm:aff id="I7">Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ertl, H C" sort="Ertl, H C" uniqKey="Ertl H" first="H. C." last="Ertl">H. C. Ertl</name><affiliation wicri:level="2"><nlm:aff id="I1">Wistar Institute, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wistar Institute, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I7">Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afforded by licensed vaccines through subtype-specific neutralizing antibodies is incomplete, especially when the vaccine antigens fail to closely match those of the circulating viral strains. Efforts are underway to generate a so-called universal influenza vaccine expressing conserved viral sequences that induce broad protection to multiple strains of influenza virus through the induction of CD8<sup>+</sup> T cells. Here we assess the effect of a potent antiviral CD8<sup>+</sup> T cell response on influenza virus infection of young and aged mice. Our results show that CD8<sup>+</sup> T cell-inducing vaccines can provide some protection to young mice, but they exacerbate influenza virus-associated disease in aged mice, causing extensive lung pathology and death.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bennett, Ak" uniqKey="Bennett A">AK Bennett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E Weintraub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E Weintraub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janssens, Jp" uniqKey="Janssens J">JP Janssens</name></author><author><name sortKey="Krause, Kh" uniqKey="Krause K">KH Krause</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stott, Dj" uniqKey="Stott D">DJ Stott</name></author><author><name sortKey="Carman, Wf" uniqKey="Carman W">WF Carman</name></author><author><name sortKey="Elder, Ag" uniqKey="Elder A">AG Elder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name></author><author><name sortKey="Bhabha, G" uniqKey="Bhabha G">G Bhabha</name></author><author><name sortKey="Elsliger, Ma" uniqKey="Elsliger M">MA Elsliger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name></author><author><name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name></author><author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleishman, Sj" uniqKey="Fleishman S">SJ Fleishman</name></author><author><name sortKey="Whitehead, Ta" uniqKey="Whitehead T">TA Whitehead</name></author><author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mozdzanowska, K" uniqKey="Mozdzanowska K">K Mozdzanowska</name></author><author><name sortKey="Feng, J" uniqKey="Feng J">J Feng</name></author><author><name sortKey="Eid, M" uniqKey="Eid M">M Eid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neirynck, S" uniqKey="Neirynck S">S Neirynck</name></author><author><name sortKey="Deroo, T" uniqKey="Deroo T">T Deroo</name></author><author><name sortKey="Saelens, X" uniqKey="Saelens X">X Saelens</name></author><author><name sortKey="Vanlandschoot, P" uniqKey="Vanlandschoot P">P Vanlandschoot</name></author><author><name sortKey="Jou, Wm" uniqKey="Jou W">WM Jou</name></author><author><name sortKey="Fiers, W" uniqKey="Fiers W">W Fiers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ulmer, Jb" uniqKey="Ulmer J">JB Ulmer</name></author><author><name sortKey="Fu, Tm" uniqKey="Fu T">TM Fu</name></author><author><name sortKey="Deck, Rr" uniqKey="Deck R">RR Deck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name></author><author><name sortKey="Smith, Gl" uniqKey="Smith G">GL Smith</name></author><author><name sortKey="Moss, B" uniqKey="Moss B">B Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimenna, L" uniqKey="Dimenna L">L DiMenna</name></author><author><name sortKey="Latimer, B" uniqKey="Latimer B">B Latimer</name></author><author><name sortKey="Parzych, E" uniqKey="Parzych E">E Parzych</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decman, V" uniqKey="Decman V">V Decman</name></author><author><name sortKey="Laidlaw, Bj" uniqKey="Laidlaw B">BJ Laidlaw</name></author><author><name sortKey="Dimenna, Lj" uniqKey="Dimenna L">LJ DiMenna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decman, V" uniqKey="Decman V">V Decman</name></author><author><name sortKey="Laidlaw, Bj" uniqKey="Laidlaw B">BJ Laidlaw</name></author><author><name sortKey="Doering, Ta" uniqKey="Doering T">TA Doering</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weksler, Me" uniqKey="Weksler M">ME Weksler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frasca, D" uniqKey="Frasca D">D Frasca</name></author><author><name sortKey="Diaz, A" uniqKey="Diaz A">A Diaz</name></author><author><name sortKey="Romero, M" uniqKey="Romero M">M Romero</name></author><author><name sortKey="Landin, Am" uniqKey="Landin A">AM Landin</name></author><author><name sortKey="Blomberg, Bb" uniqKey="Blomberg B">BB Blomberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eaton, Sm" uniqKey="Eaton S">SM Eaton</name></author><author><name sortKey="Burns, Em" uniqKey="Burns E">EM Burns</name></author><author><name sortKey="Kusser, K" uniqKey="Kusser K">K Kusser</name></author><author><name sortKey="Randall, Td" uniqKey="Randall T">TD Randall</name></author><author><name sortKey="Haynes, L" uniqKey="Haynes L">L Haynes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lazuardi, L" uniqKey="Lazuardi L">L Lazuardi</name></author><author><name sortKey="Jenewein, B" uniqKey="Jenewein B">B Jenewein</name></author><author><name sortKey="Wolf, Am" uniqKey="Wolf A">AM Wolf</name></author><author><name sortKey="Pfister, G" uniqKey="Pfister G">G Pfister</name></author><author><name sortKey="Tzankov, A" uniqKey="Tzankov A">A Tzankov</name></author><author><name sortKey="Grubeck Loebenstein, B" uniqKey="Grubeck Loebenstein B">B Grubeck-Loebenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Stedra, J" uniqKey="Stedra J">J Stedra</name></author><author><name sortKey="Cerny, J" uniqKey="Cerny J">J Cerny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weng, Np" uniqKey="Weng N">NP Weng</name></author><author><name sortKey="Akbar, An" uniqKey="Akbar A">AN Akbar</name></author><author><name sortKey="Goronzy, J" uniqKey="Goronzy J">J Goronzy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franceschi, C" uniqKey="Franceschi C">C Franceschi</name></author><author><name sortKey="Bonafe, M" uniqKey="Bonafe M">M Bonafè</name></author><author><name sortKey="Valensin, S" uniqKey="Valensin S">S Valensin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yager, Ej" uniqKey="Yager E">EJ Yager</name></author><author><name sortKey="Ahmed, M" uniqKey="Ahmed M">M Ahmed</name></author><author><name sortKey="Lanzer, K" uniqKey="Lanzer K">K Lanzer</name></author><author><name sortKey="Randall, Td" uniqKey="Randall T">TD Randall</name></author><author><name sortKey="Woodland, Dl" uniqKey="Woodland D">DL Woodland</name></author><author><name sortKey="Blackman, Ma" uniqKey="Blackman M">MA Blackman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, D" uniqKey="Zhou D">D Zhou</name></author><author><name sortKey="Wu, Tl" uniqKey="Wu T">TL Wu</name></author><author><name sortKey="Lasaro, Mo" uniqKey="Lasaro M">MO Lasaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kapasi, Zf" uniqKey="Kapasi Z">ZF Kapasi</name></author><author><name sortKey="Murali Krishna, K" uniqKey="Murali Krishna K">K Murali-Krishna</name></author><author><name sortKey="Mcrae, Ml" uniqKey="Mcrae M">ML McRae</name></author><author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daynes, Ra" uniqKey="Daynes R">RA Daynes</name></author><author><name sortKey="Enioutina, Ey" uniqKey="Enioutina E">EY Enioutina</name></author><author><name sortKey="Jones, Dc" uniqKey="Jones D">DC Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scherle, Pa" uniqKey="Scherle P">PA Scherle</name></author><author><name sortKey="Palladino, G" uniqKey="Palladino G">G Palladino</name></author><author><name sortKey="Gerhard, W" uniqKey="Gerhard W">W Gerhard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamere, Mw" uniqKey="Lamere M">MW LaMere</name></author><author><name sortKey="Lam, H T" uniqKey="Lam H">H-T Lam</name></author><author><name sortKey="Moquin, A" uniqKey="Moquin A">A Moquin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, J" uniqKey="Feng J">J Feng</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Mozdzanowska, K" uniqKey="Mozdzanowska K">K Mozdzanowska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alam, S" uniqKey="Alam S">S Alam</name></author><author><name sortKey="Sant, Aj" uniqKey="Sant A">AJ Sant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teijaro, Jr" uniqKey="Teijaro J">JR Teijaro</name></author><author><name sortKey="Turner, D" uniqKey="Turner D">D Turner</name></author><author><name sortKey="Pham, Q" uniqKey="Pham Q">Q Pham</name></author><author><name sortKey="Wherry, Ej" uniqKey="Wherry E">EJ Wherry</name></author><author><name sortKey="Lefrancois, L" uniqKey="Lefrancois L">L Lefrançois</name></author><author><name sortKey="Farber, Dl" uniqKey="Farber D">DL Farber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilkinson, Tm" uniqKey="Wilkinson T">TM Wilkinson</name></author><author><name sortKey="Li, Ckf" uniqKey="Li C">CKF Li</name></author><author><name sortKey="Chui, Csc" uniqKey="Chui C">CSC Chui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashraf, S" uniqKey="Ashraf S">S Ashraf</name></author><author><name sortKey="Kong, W" uniqKey="Kong W">W Kong</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Curtiss, R" uniqKey="Curtiss R">R Curtiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author><author><name sortKey="Kong, Wp" uniqKey="Kong W">WP Kong</name></author><author><name sortKey="Misplon, Ja" uniqKey="Misplon J">JA Misplon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, L" uniqKey="Guo L">L Guo</name></author><author><name sortKey="Zheng, M" uniqKey="Zheng M">M Zheng</name></author><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawson, Cm" uniqKey="Lawson C">CM Lawson</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name></author><author><name sortKey="Restifo, Np" uniqKey="Restifo N">NP Restifo</name></author><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author><author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hufford, Mm" uniqKey="Hufford M">MM Hufford</name></author><author><name sortKey="Kim, Ts" uniqKey="Kim T">TS Kim</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name></author><author><name sortKey="Braciale, Tj" uniqKey="Braciale T">TJ Braciale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karageorgopoulos, De" uniqKey="Karageorgopoulos D">DE Karageorgopoulos</name></author><author><name sortKey="Vouloumanou, Ek" uniqKey="Vouloumanou E">EK Vouloumanou</name></author><author><name sortKey="Korbila, Ip" uniqKey="Korbila I">IP Korbila</name></author><author><name sortKey="Kapaskelis, A" uniqKey="Kapaskelis A">A Kapaskelis</name></author><author><name sortKey="Falagas, Me" uniqKey="Falagas M">ME Falagas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hancock, K" uniqKey="Hancock K">K Hancock</name></author><author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V Veguilla</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hillaire, Mlb" uniqKey="Hillaire M">MLB Hillaire</name></author><author><name sortKey="Van Trierum, Se" uniqKey="Van Trierum S">SE van Trierum</name></author><author><name sortKey="Kreijtz, Jhcm" uniqKey="Kreijtz J">JHCM Kreijtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heinen, Pp" uniqKey="Heinen P">PP Heinen</name></author><author><name sortKey="Rijsewijks, Fa" uniqKey="Rijsewijks F">FA Rijsewijks</name></author><author><name sortKey="De Boer Luitjtze, Ea" uniqKey="De Boer Luitjtze E">EA de Boer-Luitjtze</name></author><author><name sortKey="Bianchi, Atj" uniqKey="Bianchi A">ATJ Bianchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author><author><name sortKey="Hui, Kpy" uniqKey="Hui K">KPY Hui</name></author><author><name sortKey="Yen, Hl" uniqKey="Yen H">HL Yen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teijaro, Jr" uniqKey="Teijaro J">JR Teijaro</name></author><author><name sortKey="Njau, Mn" uniqKey="Njau M">MN Njau</name></author><author><name sortKey="Verhoeven, D" uniqKey="Verhoeven D">D Verhoeven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marcelin, G" uniqKey="Marcelin G">G Marcelin</name></author><author><name sortKey="Aldridge, Jr" uniqKey="Aldridge J">JR Aldridge</name></author><author><name sortKey="Duan, S" uniqKey="Duan S">S Duan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longhi, Mp" uniqKey="Longhi M">MP Longhi</name></author><author><name sortKey="Williams, A" uniqKey="Williams A">A Williams</name></author><author><name sortKey="Wise, M" uniqKey="Wise M">M Wise</name></author><author><name sortKey="Morgan, Bp" uniqKey="Morgan B">BP Morgan</name></author><author><name sortKey="Gallimore, A" uniqKey="Gallimore A">A Gallimore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmitz, N" uniqKey="Schmitz N">N Schmitz</name></author><author><name sortKey="Kurrer, M" uniqKey="Kurrer M">M Kurrer</name></author><author><name sortKey="Bachmann, Mf" uniqKey="Bachmann M">MF Bachmann</name></author><author><name sortKey="Kopf, M" uniqKey="Kopf M">M Kopf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crowe, Cr" uniqKey="Crowe C">CR Crowe</name></author><author><name sortKey="Chen, K" uniqKey="Chen K">K Chen</name></author><author><name sortKey="Pociask, Da" uniqKey="Pociask D">DA Pociask</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author><author><name sortKey="Yoon, H" uniqKey="Yoon H">H Yoon</name></author><author><name sortKey="Zhao, Mq" uniqKey="Zhao M">MQ Zhao</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Ramana, Cv" uniqKey="Ramana C">CV Ramana</name></author><author><name sortKey="Enelow, Ri" uniqKey="Enelow R">RI Enelow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pereira, Lf" uniqKey="Pereira L">LF Pereira</name></author><author><name sortKey="De Souza, Ap" uniqKey="De Souza A">AP de Souza</name></author><author><name sortKey="Borges, Tj" uniqKey="Borges T">TJ Borges</name></author><author><name sortKey="Bonorino, C" uniqKey="Bonorino C">C Bonorino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Cp" uniqKey="Wong C">CP Wong</name></author><author><name sortKey="Magnusson, Kr" uniqKey="Magnusson K">KR Magnusson</name></author><author><name sortKey="Ho, E" uniqKey="Ho E">E Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="La Gruta, Nl" uniqKey="La Gruta N">NL La Gruta</name></author><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name></author><author><name sortKey="Stambas, J" uniqKey="Stambas J">J Stambas</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, F" uniqKey="Zhou F">F Zhou</name></author><author><name sortKey="Onizawa, S" uniqKey="Onizawa S">S Onizawa</name></author><author><name sortKey="Nagai, A" uniqKey="Nagai A">A Nagai</name></author><author><name sortKey="Aoshiba, K" uniqKey="Aoshiba K">K Aoshiba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiang, Z" uniqKey="Xiang Z">Z Xiang</name></author><author><name sortKey="Gao, G" uniqKey="Gao G">G Gao</name></author><author><name sortKey="Reyes Sandoval, A" uniqKey="Reyes Sandoval A">A Reyes-Sandoval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fitzgerald, Jc" uniqKey="Fitzgerald J">JC Fitzgerald</name></author><author><name sortKey="Gao, Gp" uniqKey="Gao G">GP Gao</name></author><author><name sortKey="Reyes Sandoval, A" uniqKey="Reyes Sandoval A">A Reyes-Sandoval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Dm" uniqKey="Brown D">DM Brown</name></author><author><name sortKey="Dilzer, Am" uniqKey="Dilzer A">AM Dilzer</name></author><author><name sortKey="Meents, Dl" uniqKey="Meents D">DL Meents</name></author><author><name sortKey="Swain, Sl" uniqKey="Swain S">SL Swain</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Parzych, E M" sort="Parzych, E M" uniqKey="Parzych E" first="E. M." last="Parzych">E. M. Parzych</name></region><name sortKey="Dimenna, L J" sort="Dimenna, L J" uniqKey="Dimenna L" first="L. J." last="Dimenna">L. J. Dimenna</name><name sortKey="Dimenna, L J" sort="Dimenna, L J" uniqKey="Dimenna L" first="L. J." last="Dimenna">L. J. Dimenna</name><name sortKey="Ertl, H C" sort="Ertl, H C" uniqKey="Ertl H" first="H. C." last="Ertl">H. C. Ertl</name><name sortKey="Ertl, H C" sort="Ertl, H C" uniqKey="Ertl H" first="H. C." last="Ertl">H. C. Ertl</name><name sortKey="Kannan, S" sort="Kannan, S" uniqKey="Kannan S" first="S." last="Kannan">S. Kannan</name><name sortKey="Kannan, S" sort="Kannan, S" uniqKey="Kannan S" first="S." last="Kannan">S. Kannan</name><name sortKey="Lasaro, M O" sort="Lasaro, M O" uniqKey="Lasaro M" first="M. O." last="Lasaro">M. O. Lasaro</name><name sortKey="Lasaro, M O" sort="Lasaro, M O" uniqKey="Lasaro M" first="M. O." last="Lasaro">M. O. Lasaro</name><name sortKey="Latimer, B P" sort="Latimer, B P" uniqKey="Latimer B" first="B. P." last="Latimer">B. P. Latimer</name><name sortKey="Latimer, B P" sort="Latimer, B P" uniqKey="Latimer B" first="B. P." last="Latimer">B. P. Latimer</name><name sortKey="Manson, B" sort="Manson, B" uniqKey="Manson B" first="B." last="Manson">B. Manson</name><name sortKey="Manson, B" sort="Manson, B" uniqKey="Manson B" first="B." last="Manson">B. Manson</name><name sortKey="Parzych, E M" sort="Parzych, E M" uniqKey="Parzych E" first="E. M." last="Parzych">E. M. Parzych</name><name sortKey="Small, J C" sort="Small, J C" uniqKey="Small J" first="J. C." last="Small">J. C. Small</name><name sortKey="Small, J C" sort="Small, J C" uniqKey="Small J" first="J. C." last="Small">J. C. Small</name><name sortKey="Wherry, E J" sort="Wherry, E J" uniqKey="Wherry E" first="E. J." last="Wherry">E. J. Wherry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000873 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000873 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3800650
|texte= Influenza Virus Specific CD8+ T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24187666" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |